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An unexpected function of a cell-cycle enzyme might explain the toxic effects of its inhibitors

Published: 10/28/2026, 12:00 AM

This is a summary of: Vuillemenot, L.-A. et al. WEE1 opposes APC/CCDH1 activity to promote S phase entry. Nature https://doi.org/10.1038/s41586-026-11188-x (2026). Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription Prices may be subject to local taxes which are calculated during checkout ‘Expert opinion’ and the figure are published under a CC BY 4.0 licence. Article PubMed Google Scholar Matheson, C. J., Backos, D. S. & Reigan, P. Trends Pharmacol. Sci. 37, 872–881 (2016). Article PubMed Google Scholar Otto, T. & Sicinski, P. Nature Rev. Cancer 17, 93–115 (2017). Article PubMed Google Scholar